Showing posts with label Nobel Prize. Show all posts
Showing posts with label Nobel Prize. Show all posts

Wednesday, October 08, 2014

The Cold Blue Firing Line


You must rise to her defense when she's in danger
Turn around and you're looking at a stranger
And leads you into places even angels fear to tread
She's a blue light.

- David Gilmour, "Blue Light" (1984)
One crucial aspect of the story of newly minted Nobel laureate Nakamura Shuji, whom the immigration bureaus and media outlets of Japan and the U.S. are fighting over (Link) is being ignored, possibly because it is truly MADE IN JAPAN. While everyone remembers the lawsuit Nakamura filed against his former employer Nichia demanding a reasonable share of the revenues the company accrued from the blue diode he developed for them (Link) no one is recalling the most telling detail of the story: Nichia executives ordered Nakamura FOR YEARS to cease and desist in his quest for the blue diode. Nichia could not, due to the extreme protections afforded by Japanese labor laws and out of concern for its reputation, actually fire its insubordinate researcher. Any other company anywhere else would have sent such an employee out the door, pronto. Nakamura could, however, pursue his dream at Nichia's expense. Nichia eventually reaped windfall profits from Nakamura's work, which the company stubbornly but not inexplicably was unwilling to share. After all Nichia had been forced into into years of bankrolling not only Nakamura's salary but his lab.

In the current discussion of the pressing necessity to reform Japan's labor laws (I remember one conference where a British finance industry analyst made reform into a sexual identity issue, baying out, "When is Japan going to man up and attack labor law reform?") advocates should be asked to concede the immense social and financial benefits that resulted from at least one Japanese company's inability to fire a rebel.

Friday, January 31, 2014

Damn You Science!



Abenomics is getting the stuffing kicked out of it this week. The Nikkei plunged 500 points yesterday, finishing the day down 376 points (-2.43%), adding to the losses since January 9. The yen has been on a mild strengthening trend, threatening earnings reporting of the big exporters. U.S. Senate Majority leader Harry Reid's rejection of a request for fast-track trade authority has put the Trans Pacific Partnership on hold.

Yesterday, Prime Minister Abe Shinzo's plans for reviving Japan's economy received another blow, this time from a bubbly 30-year old girl geek in pearl earrings.
Stem cell 'major discovery' claimed
BBC News

Scientists in Japan showed stem cells can now be made quickly just by dipping blood cells into acid.

Stem cells can transform into any tissue and are already being trialled for healing the eye, heart and brain.

The latest development, published in the journal Nature, could make the technology cheaper, faster and safer.

The human body is built of cells with a specific role - nerve cells, liver cells, muscle cells - and that role is fixed.

However, stem cells can become any other type of cell, and they have become a major field of research in medicine for their potential to regenerate the body.

Embryos are one, ethically charged, source of stem cells. Nobel prize winning research also showed that skin cells could be "genetically reprogrammed" to become stem cells (termed induced pluripotent stem cells).

Acid bath

Now a study shows that shocking blood cells with acid could also trigger the transformation into stem cells - this time termed STAP (stimulus-triggered acquisition of pluripotency) cells.

Dr Haruko Obokata, from the Riken Centre for Developmental Biology in Japan, said she was "really surprised" that cells could respond to their environment in this way.

She added: "It's exciting to think about the new possibilities these findings offer us, not only in regenerative medicine, but cancer as well."

(Link)

Dr. Obokata's paper was published in Nature, whose account of the discovery (Link) fails to mention that it rejected her original paper. According to last night's NHK report, the reviewer told her that her results, if true, would contradict 100 years of research into cellular biology.

The coverage of Dr. Obokata's new pathway to stem cells has been lavish and fawning (Link - J video) -- which is rather inconvenient for Prime Minister Abe. He already has his stem cell hero, Nobel laureate Yamanaka Shinya. They have a mutually beneficial relationship, Mr. Abe plying Dr. Yamanaka with honors (Link) and cash (Link). Dr. Yamanaka's patented induced pluripotent pathway to stem cells was supposed to be the nucleus of a bio-engineering revolution, a showcase of Japanese prowess in technological and business development -- and Mr. Abe was going to be its munificent and enthusiastic patron.

Now here comes this lacrosse-playing, turtle-keeping, media darling young lab rat with a method of creating stem cells that is cheaper, more efficient, faster and with fewer potential complications than Dr. Yamanaka's.

It must all seem so unfair.

Original image courtesy: BBC